Category: Mood Disorders

Hot Topics: Treating Depression May Counteract Cognitive Impairments

Jackie Werner Alzheimer Disease, Geriatrics, Hot Topics in Research, Mood Disorders

Neuropsychiatric Symptoms and the Diagnostic Stability of Mild Cognitive Impairment Sugarman MA, Alosco ML, Tripodis Y, Steinberg EG, Stern RA. Neuropsychiatric symptoms and the diagnostic stability of mild cognitive impairment. Journal of Alzheimer’s Disease. 2018:1-15. doi: 10.3233/JAD-170527. Background: Mild cognitive impairment (MCI) is an intermediate diagnosis between normal cognition (NC) and dementia, including Alzheimer’s disease (AD) dementia. However, MCI is heterogeneous; many individuals subsequently revert to NC while others remain stable at MCI for several years. Identifying factors associated with this diagnostic instability could assist in defining clinical populations and determining cognitive prognoses. Objective: The current study examined whether neuropsychiatric…

Hot Topics: Key Molecule Found To Protect Brain From Depression

Jackie Werner Hot Topics in Research, Mood Disorders, Psychology and Psychiatry

Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation Amorim IS, Kedia S, Kouloulia S, et al. Loss of eIF4E phosphorylation engenders depression-like behaviors via selective mRNA translation. J Neurosci. 2018;38(8):2118-2133. doi: 10.1523/JNEUROSCI.2673-17.2018. The MAPK/ERK (mitogen-activated protein kinases/extracellular signal-regulated kinase) pathway is a cardinal regulator of synaptic plasticity, learning, and memory in the hippocampus. One of major endpoints of this signaling cascade is the 5′ mRNA cap binding protein eIF4E (eukaryotic Initiation Factor 4E), which is phosphorylated on Ser 209 by MNK (MAPK-interacting protein kinases) and controls mRNA translation. The precise role of phospho-eIF4E in the brain is yet to…

Hot Topics: Daily Light Therapy May Provide Relief for Bipolar Depression

Jackie Werner Hot Topics in Research, Mood Disorders, Psychology and Psychiatry

Adjunctive Bright Light Therapy for Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Trial Sit, D. K., McGowan, J., Wiltrout, C., Diler, R. S., Dills, J., et al. (2017). Adjunctive bright light therapy for bipolar depression: A randomized double-blind placebo-controlled trial. American Journal of Psychiatry. doi:10.1176/appi.ajp.2017.16101200 Objective: Patients with bipolar disorder have recurrent major depression, residual mood symptoms, and limited treatment options. Building on promising pilot data, the authors conducted a 6-week randomized double-blind placebo-controlled trial to investigate the efficacy of adjunctive bright light therapy at midday for bipolar depression. The aims were to determine remission rate, depression symptom level, and rate of…

Hot Topics: Common Gene Sets Link Bipolar Disorder, Major Depression, and Schizophrenia

Jackie Werner Hot Topics in Research, January, Mood Disorders, Psychology and Psychiatry, Schizophrenia

Consistently altered expression of gene sets in postmortem brains of individuals with major psychiatric disorders Darby M,M., Yolken R,H., Sabunciyan S. Consistently altered expression of gene sets in postmortem brains of individuals with major psychiatric disorders. Transl Psychiatry. 2016;6:e890. http://dx.doi.org/10.1038/tp.2016.173. The measurement of gene expression in postmortem brain is an important tool for understanding the pathogenesis of serious psychiatric disorders. We hypothesized that major molecular deficits associated with psychiatric disease would affect the entire brain, and such deficits may be shared across disorders. We performed RNA sequencing and quantified gene expression in the hippocampus of 100 brains in the Stanley…