PCOM Library / Hot Topics in Research / Archive for "Pharmaceutical Sciences"

Category: Pharmaceutical Sciences

Hot Topics: Animal Model May Show How to Reduce Chemotherapy Pain

Jackie Werner Hot Topics in Research, Oncology, Pharmaceutical Sciences

Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms Wahlman C, Doyle TM, Little JW, et al. Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms. Pain. doi: 10.1097/j.pain.0000000000001177 Development of chemotherapy-induced neuropathic pain (CINP) compromises the use of chemotherapy and greatly impacts thousands of lives. Unfortunately, there are no Food and Drug Administration–approved drugs to prevent or treat CINP. Neuropathological changes within CNS, including neuroinflammation and increased neuronal excitability, are driven by alterations in neuro-glia communication; but, the molecular signaling pathways remain largely unexplored. Adenosine is a potent neuroprotective purine nucleoside released to counteract the…

Hot Topics: Ingestible Sensors Can Tell If Patients Are Taking Pills

Jackie Werner Hot Topics in Research, Pharmaceutical Sciences

Oxycodone Ingestion Patterns in Acute Fracture Pain With Digital Pills Chai PR, Carreiro S, Innes BJ, et al. Oxycodone ingestion patterns in acute fracture pain with digital pills. Anesthesia & Analgesia. 2017;125(6). doi: 10.1213/ANE.0000000000002574 BACKGROUND: Opioid analgesics are commonly prescribed on an as-needed (PRN) basis for acute painful conditions. Uncertainty of how patients actually take PRN opioids, coupled with a desire to completely cover pain, leads to variable and overly generous opioid prescribing practices, resulting in a surplus of opioids. This opioid surplus becomes a source for diversion and nonmedical opioid use. Understanding patterns of actual opioid ingestion after acute painful conditions can…

Hot Topics: Unnecessary Antibiotics in Hospitals Can Cause Adverse Events

Jackie Werner Hot Topics in Research, Internal Medicine, Pharmaceutical Sciences

Association of Adverse Events With Antibiotic Use in Hospitalized Patients Tamma PD, Avdic E, Li DX, Dzintars K, Cosgrove SE. Association of Adverse Events With Antibiotic Use in Hospitalized Patients. JAMA Intern Med. Published online June 12, 2017. doi:10.1001/jamainternmed.2017.1938 Importance  Estimates of the incidence of overall antibiotic-associated adverse drug events (ADEs) in hospitalized patients are generally unavailable. Objective  To describe the incidence of antibiotic-associated ADEs for adult inpatients receiving systemic antibiotic therapy. Design, Setting, and Participants  Retrospective cohort of adult inpatients admitted to general medicine wards at an academic medical center. Exposures  At least 24 hours of any parenteral or oral antibiotic therapy. Main Outcomes and…

Hot Topics: Many Drugs Face Safety Issues After FDA Approval

Jackie Werner Hot Topics in Research, Pharmaceutical Sciences

Postmarket Safety Events Among Novel Therapeutics Approved by the US Food and Drug Administration Between 2001 and 2010 Downing NS, Shah ND, Aminawung JA, et al. Postmarket safety events among novel therapeutics approved by the US food and drug administration between 2001 and 2010. JAMA. 2017;317(18):1854-1863. doi: 10.1001/jama.2017.5150. Importance  Postmarket safety events of novel pharmaceuticals and biologics occur when new safety risks are identified after initial regulatory approval of these therapeutics. These safety events can change how novel therapeutics are used in clinical practice and inform patient and clinician decision making. Objectives  To characterize the frequency of postmarket safety events…