PCOM Library / Hot Topics in Research / Internal Medicine / Archive for "Infectious Disease"

Category: Infectious Disease

Hot Topics: Monthly Injections Could Replace Pills for HIV Treatment

Jackie Werner Hot Topics in Research, Infectious Disease

Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial Margolis DA, Gonzalez-Garcia J, Stellbrink H, et al. Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial. The Lancet. http://dx.doi.org/10.1016/S0140-6736(17)31917-7. Summary Background Cabotegravir and rilpivirine are antiretroviral drugs in development as long-acting injectable formulations. The LATTE-2 study evaluated long-acting cabotegravir plus rilpivirine for maintenance of HIV-1 viral suppression through 96 weeks. Methods In this randomised, phase 2b, open-label study, treatment-naive adults infected with HIV-1 initially received oral cabotegravir 30…

Hot Topics: Most Pediatric Flu Deaths Could Be Prevented With Flu Shot

Jackie Werner Hot Topics in Research, Infectious Disease

Influenza vaccine effectiveness against pediatric deaths: 2010–2014 Flannery B, Reynolds SB, Blanton L, et al. Influenza vaccine effectiveness against pediatric deaths: 2010–2014. Pediatrics. 2017;139(5). doi: 10.1542/peds.2016-4244. BACKGROUND AND OBJECTIVES: Surveillance for laboratory-confirmed influenza-associated pediatric deaths since 2004 has shown that most deaths occur in unvaccinated children. We assessed whether influenza vaccination reduced the risk of influenza-associated death in children and adolescents. METHODS: We conducted a case–cohort analysis comparing vaccination uptake among laboratory-confirmed influenza-associated pediatric deaths with estimated vaccination coverage among pediatric cohorts in the United States. Case vaccination and high-risk status were determined by case investigation. Influenza vaccination coverage estimates…

Hot Topics: More Species of Mosquitos Than Previously Thought May Transmit Zika

Jackie Werner Hot Topics in Research, Infectious Disease

Data-driven identification of potential Zika virus vectors Evans MV, Dallas TA, Han BA, Murdock CC, Drake JM. Data-driven identification of potential zika virus vectors. eLife. 2017;6:e22053. https://dx.doi.org/10.7554/eLife.22053. Zika is an emerging virus whose rapid spread is of great public health concern. Knowledge about transmission remains incomplete, especially concerning potential transmission in geographic areas in which it has not yet been introduced. To identify unknown vectors of Zika, we developed a data-driven model linking vector species and the Zika virus via vector-virus trait combinations that confer a propensity toward associations in an ecological network connecting flaviviruses and their mosquito vectors. Our…

Hot Topics: Experimental Ebola Vaccine Gives 100% Protection

Jackie Werner Hot Topics in Research, Infectious Disease, Internal Medicine, January

Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!) Henao-Restrepo A, Camacho A, Longini IM, et al. Efficacy and effectiveness of an rVSV-vectored vaccine in preventing ebola virus disease: Final results from the guinea ring vaccination, open-label, cluster-randomised trial (ebola ça suffit!). The Lancet. http://dx.doi.org/10.1016/S0140-6736(16)32621-6. Background rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus. We tested the effect of rVSV-ZEBOV in preventing Ebola virus disease in contacts and contacts of contacts of recently confirmed…