Category: Biomedical Sciences

Hot Topics: Transcriptional Regulator CTCF Found Essential in Immune Response

Jackie Werner Biomedical Sciences, Hot Topics in Research

CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation Pérez-Garcí­a A, Marina-Zárate E, Álvarez-Prado ÁF, Ligos JM, Galjart N, Ramiro AR. CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation. Nature Communications. 2017;8:16067. http://dx.doi.org/10.1038/ncomms16067. In germinal centres (GC) mature B cells undergo intense proliferation and immunoglobulin gene modification before they differentiate into memory B cells or long-lived plasma cells (PC). GC B-cell-to-PC transition involves a major transcriptional switch that promotes a halt in cell proliferation and the production of secreted immunoglobulins. Here we show that the CCCTC-binding factor (CTCF) is required for the…