Zebrafish Reel in Phenotypic Suppressors of Autism
Chemical genetics can help decipher novel pathways underlying neurodevelopmental psychiatric impairments. Hoffman et al. (2016) utilized behavioral profiling of psychoactive compounds in zebrafish and identified estrogens as suppressors of a phenotype resulting from loss of an autism risk gene.
Neuron, Volume 89, Issue 4, 17 February 2016, Pages 673–675