Author: Jackie Werner

Hot Topics: Customized 3-D Models Effectively Train Children’s Surgeons

Jackie Werner Front Page, Hot Topics in Research, Pediatrics, Surgery

Patient-specific 3D models aid planning for triplane proximal femoral osteotomy in slipped capital femoral epiphysis Cherkasskiy L, Caffrey JP, Szewczyk AF, et al. Patient-specific 3D models aid planning for triplane proximal femoral osteotomy in slipped capital femoral epiphysis. J Child Orthop. 2017;11(2):147-153. https://doi.org/10.1302/1863-2548-11-170277. Purpose Slipped capital femoral epiphysis (SCFE) can result in a complex three-dimensional (3D) deformity of the proximal femur. A three-plane proximal femoral osteotomy (TPFO) has been described to improve hip mechanics. The purpose of this study was to evaluate the benefits of using 3D print technology to aid in surgical planning. Patients and Methods Fifteen children treated with TPFO…

Hot Topics: Anti-Statin Internet Trend Could Threaten Lives

Jackie Werner Cardiology, Front Page, Hot Topics in Research

Statin Denial: An Internet-Driven Cult With Deadly Consequences Nissen SE. Statin Denial: An Internet-Driven Cult With Deadly Consequences. Ann Intern Med. doi: 10.7326/M17-1566 The reduction in cardiovascular morbidity and mortality during the past 3 decades represents one of the great triumphs of contemporary medicine. In 1987, the age-adjusted mortality rate in the U.S. population for cardiovascular disease was 357 in 100 000, decreasing to 167 in 100 000 by 2014 (1). Although precisely gauging the relative contributions of various public health measures to the decline in cardiovascular morbidity and mortality is impossible, most critical observers consider the introduction of statins in 1987…

Hot Topics: Monthly Injections Could Replace Pills for HIV Treatment

Jackie Werner Hot Topics in Research, Infectious Disease

Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial Margolis DA, Gonzalez-Garcia J, Stellbrink H, et al. Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial. The Lancet. http://dx.doi.org/10.1016/S0140-6736(17)31917-7. Summary Background Cabotegravir and rilpivirine are antiretroviral drugs in development as long-acting injectable formulations. The LATTE-2 study evaluated long-acting cabotegravir plus rilpivirine for maintenance of HIV-1 viral suppression through 96 weeks. Methods In this randomised, phase 2b, open-label study, treatment-naive adults infected with HIV-1 initially received oral cabotegravir 30…

Hot Topics: Transcriptional Regulator CTCF Found Essential in Immune Response

Jackie Werner Biomedical Sciences, Hot Topics in Research

CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation Pérez-Garcí­a A, Marina-Zárate E, Álvarez-Prado ÁF, Ligos JM, Galjart N, Ramiro AR. CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation. Nature Communications. 2017;8:16067. http://dx.doi.org/10.1038/ncomms16067. In germinal centres (GC) mature B cells undergo intense proliferation and immunoglobulin gene modification before they differentiate into memory B cells or long-lived plasma cells (PC). GC B-cell-to-PC transition involves a major transcriptional switch that promotes a halt in cell proliferation and the production of secreted immunoglobulins. Here we show that the CCCTC-binding factor (CTCF) is required for the…

Hot Topics: Unnecessary Antibiotics in Hospitals Can Cause Adverse Events

Jackie Werner Hot Topics in Research, Internal Medicine, Pharmaceutical Sciences

Association of Adverse Events With Antibiotic Use in Hospitalized Patients Tamma PD, Avdic E, Li DX, Dzintars K, Cosgrove SE. Association of Adverse Events With Antibiotic Use in Hospitalized Patients. JAMA Intern Med. Published online June 12, 2017. doi:10.1001/jamainternmed.2017.1938 Importance  Estimates of the incidence of overall antibiotic-associated adverse drug events (ADEs) in hospitalized patients are generally unavailable. Objective  To describe the incidence of antibiotic-associated ADEs for adult inpatients receiving systemic antibiotic therapy. Design, Setting, and Participants  Retrospective cohort of adult inpatients admitted to general medicine wards at an academic medical center. Exposures  At least 24 hours of any parenteral or oral antibiotic therapy. Main Outcomes and…

Hot Topics: SIDS Infants Show High Levels of Serotonin in Blood

Jackie Werner Hot Topics in Research, Pediatrics

High serum serotonin in sudden infant death syndrome Haynes RL, Frelinger AL, Giles EK, et al. High serum serotonin in sudden infant death syndrome. Proceedings of the National Academy of Sciences. 2017. doi: 10.1073/pnas.1617374114. Sudden infant death syndrome (SIDS), the leading cause of postneonatal infant mortality, likely comprises heterogeneous disorders with the common phenotype of sudden death without explanation upon postmortem investigation. Previously, we reported that ∼40% of SIDS deaths are associated with abnormalities in serotonin (5-hydroxytryptamine, 5-HT) in regions of the brainstem critical in homeostatic regulation. Here we tested the hypothesis that SIDS is associated with an alteration in serum…

Hot Topics: Alzheimer’s Further Linked to Brain Plaques

Jackie Werner Alzheimer Disease, Hot Topics in Research, Senile Plaques

Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons Donohue MC, Sperling RA, Petersen R, al e. Association between elevated brain amyloid and subsequent cognitive decline among cognitively normal persons. JAMA. 2017. 317(22):2305-2316. doi: 10.1001/jama.2017.6669. Importance  Among cognitively normal individuals, elevated brain amyloid (defined by cerebrospinal fluid assays or positron emission tomography regional summaries) can be related to risk for later Alzheimer-related cognitive decline. Objective  To characterize and quantify the risk for Alzheimer-related cognitive decline among cognitively normal individuals with elevated brain amyloid. Design, Setting, and Participants  Exploratory analyses were conducted with longitudinal cognitive and biomarker data from 445…

Hot Topics: Benefits of Autism Diets and Supplements Questionable

Jackie Werner Developmental Disorders, Hot Topics in Research

Nutritional and Dietary Interventions for Autism Spectrum Disorder: A Systematic Review Sathe N, Andrews JC, McPheeters ML, Warren ZE. Nutritional and dietary interventions for autism spectrum disorder: A systematic review. Pediatrics. 2017. doi: 10.1542/peds.2017-0346 CONTEXT: Children with autism spectrum disorder (ASD) frequently use special diets or receive nutritional supplements to treat ASD symptoms. OBJECTIVES: Our objective was to evaluate the effectiveness and safety of dietary interventions or nutritional supplements in ASD. DATA SOURCES: Databases, including Medline and PsycINFO. STUDY SELECTION: Two investigators independently screened studies against predetermined criteria. DATA EXTRACTION: One investigator extracted data with review by a second investigator….

Hot Topics: Many Drugs Face Safety Issues After FDA Approval

Jackie Werner Hot Topics in Research, Pharmaceutical Sciences

Postmarket Safety Events Among Novel Therapeutics Approved by the US Food and Drug Administration Between 2001 and 2010 Downing NS, Shah ND, Aminawung JA, et al. Postmarket safety events among novel therapeutics approved by the US food and drug administration between 2001 and 2010. JAMA. 2017;317(18):1854-1863. doi: 10.1001/jama.2017.5150. Importance  Postmarket safety events of novel pharmaceuticals and biologics occur when new safety risks are identified after initial regulatory approval of these therapeutics. These safety events can change how novel therapeutics are used in clinical practice and inform patient and clinician decision making. Objectives  To characterize the frequency of postmarket safety events…

Hot Topics: Severe Epilepsy Eased by Compound in Cannabis

Jackie Werner Hot Topics in Research, Neurology

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome Devinsky O, Cross JH, Laux L, et al. Trial of cannabidiol for drug-resistant seizures in the dravet syndrome. N Engl J Med. 2017;376(21):2011-2020. http://dx.doi.org/10.1056/NEJMoa1611618. BACKGROUND The Dravet syndrome is a complex childhood epilepsy disorder that is associated with drug-resistant seizures and a high mortality rate. We studied cannabidiol for the treatment of drug-resistant seizures in the Dravet syndrome. METHODS In this double-blind, placebo-controlled trial, we randomly assigned 120 children and young adults with the Dravet syndrome and drug-resistant seizures to receive either cannabidiol oral solution at a dose of 20…