Month: January 2017

ScienceDirect Technical Issue

Richard Saldivar Front Page, Library News, Service Disruptions

Due to a technical issue, some users are experiencing trouble accessing ScienceDirect content off-campus. If you experience trouble, try re-accessing ScienceDirect through this link or by installing the Remote Access Bookmarklet and clicking the bookmarklet while on ScienceDirect to reload the page through the library’s proxy. Please contact us if you have any questions.

Hot Topics: Bed Cycling Safe for ICU Patients

Jackie Werner Critical Care, Hot Topics in Research, January, Physical Therapy

TryCYCLE: A Prospective Study of the Safety and Feasibility of Early In-Bed Cycling in Mechanically Ventilated Patients Kho ME, Molloy AJ, Clarke FJ, et al. TryCYCLE: A prospective study of the safety and feasibility of early in-bed cycling in mechanically ventilated patients. PLOS ONE. 2016;11(12):e0167561. Introduction The objective of this study was to assess the safety and feasibility of in-bed cycling started within the first 4 days of mechanical ventilation (MV) to inform a future randomized clinical trial. Methods We conducted a 33-patient prospective cohort study in a 21-bed adult academic medical-surgical intensive care unit (ICU) in Hamilton, ON, Canada….

Hot Topics: Lifestyle Makes a Difference in Heart Disease

Jackie Werner Cardiology, Hot Topics in Research, Internal Medicine, January

Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease Khera AV, Emdin CA, Drake I, et al. Genetic risk, adherence to a healthy lifestyle, and coronary disease. N Engl J Med. 2016;375(24):2349-2358. http://dx.doi.org/10.1056/NEJMoa1605086. BACKGROUND Both genetic and lifestyle factors contribute to individual-level risk of coronary artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle is unknown. METHODS Using a polygenic score of DNA sequence polymorphisms, we quantified genetic risk for coronary artery disease in three prospective cohorts — 7814 participants in the Atherosclerosis Risk in Communities (ARIC) study, 21,222 in the Women’s…

Hot Topics: Experimental Ebola Vaccine Gives 100% Protection

Jackie Werner Hot Topics in Research, Infectious Disease, Internal Medicine, January

Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!) Henao-Restrepo A, Camacho A, Longini IM, et al. Efficacy and effectiveness of an rVSV-vectored vaccine in preventing ebola virus disease: Final results from the guinea ring vaccination, open-label, cluster-randomised trial (ebola ça suffit!). The Lancet. http://dx.doi.org/10.1016/S0140-6736(16)32621-6. Background rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus. We tested the effect of rVSV-ZEBOV in preventing Ebola virus disease in contacts and contacts of contacts of recently confirmed…

Hot Topics: Common Gene Sets Link Bipolar Disorder, Major Depression, and Schizophrenia

Jackie Werner Hot Topics in Research, January, Mood Disorders, Psychology and Psychiatry, Schizophrenia

Consistently altered expression of gene sets in postmortem brains of individuals with major psychiatric disorders Darby M,M., Yolken R,H., Sabunciyan S. Consistently altered expression of gene sets in postmortem brains of individuals with major psychiatric disorders. Transl Psychiatry. 2016;6:e890. http://dx.doi.org/10.1038/tp.2016.173. The measurement of gene expression in postmortem brain is an important tool for understanding the pathogenesis of serious psychiatric disorders. We hypothesized that major molecular deficits associated with psychiatric disease would affect the entire brain, and such deficits may be shared across disorders. We performed RNA sequencing and quantified gene expression in the hippocampus of 100 brains in the Stanley…