Month: March 2016

Low-Dose Acetylsalicylic Acid Treatment and Impact on Short-Term Mortality in Staphylococcus aureus Bloodstream Infection: A Propensity Score–Matched Cohort Study

PJ Grier April, Cardiology, Hot Topics in Research

Low-Dose Acetylsalicylic Acid Treatment and Impact on Short-Term Mortality in Staphylococcus aureus Bloodstream Infection: A Propensity Score–Matched Cohort Study Abstract Objectives: Staphylococcus aureus bloodstream infection is associated with considerable mortality. Experimental models suggest a direct antistaphylococcal effect of acetylsalicylic acid, but evidence from human studies is scarce. We aimed to estimate the effect of low-dose acetylsalicylic acid therapy on mortality in bloodstream infections caused by S. aureus compared with Escherichia coli. Design: Retrospective cohort study based on observational data from 838 and 602 episodes of S. aureus and E. coli bloodstream infection, respectively. Setting: Swiss tertiary referral center. Patients: Adult…

Association of Child Poverty, Brain Development, and Academic Achievement

PJ Grier April, Brain, Hot Topics in Research

Association of Child Poverty, Brain Development, and Academic Achievement Importance  Children living in poverty generally perform poorly in school, with markedly lower standardized test scores and lower educational attainment. The longer children live in poverty, the greater their academic deficits. These patterns persist to adulthood, contributing to lifetime-reduced occupational attainment. Objective  To determine whether atypical patterns of structural brain development mediate the relationship between household poverty and impaired academic performance. Design, Setting, and Participants  Longitudinal cohort study analyzing 823 magnetic resonance imaging scans of 389 typically developing children and adolescents aged 4 to 22 years from the National Institutes of…

Association Between Treatment at a High-Volume Facility and Improved Survival for Radiation-Treated Men With High-Risk Prostate Cancer

PJ Grier April, Hot Topics in Research, Oncology, Prostate

Association Between Treatment at a High-Volume Facility and Improved Survival for Radiation-Treated Men With High-Risk Prostate Cancer Purpose: Although the association between higher hospital volume and improved outcomes has been well-documented in surgery, there is little data about whether this effect exists for radiation-treated patients. We investigated whether treatment at a radiation facility that treats a high volume of prostate cancer patients is associated with improved survival for men with high-risk prostate cancer. Methods and Materials: We used the National Cancer Database (NCDB) to identity patients diagnosed with prostate cancer from 2004 to 2006. The radiation case volume (RCV) of each…

Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue

PJ Grier Alzheimer Disease, April, Hot Topics in Research

Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue Abstract  The accumulation of neurofibrillary tangles, composed of aggregated hyperphosphorylated tau protein, starts spreading early in specific regions in the course of Alzheimer’s disease (AD), correlating with the progression of memory dysfunction. The non-invasive imaging of tau could therefore facilitate the early diagnosis of AD, differentiate it from other dementing disorders and allow evaluation of tau immunization therapy outcomes. In this study we characterized the in vitro binding properties of THK5117, a tentative radiotracer for positron emission tomography (PET) imaging of tau brain deposits. Results Saturation and competition binding…

Library OneSearch+ Reading Lists

Richard Saldivar Front Page, Library News

We are proud to announce the availability of Library OneSearch+ Reading Lists! PCOM Library OneSearch+ Reading Lists offers faculty an easy way to create and manage course reading lists directly inside Blackboard. Library OneSearch+ Reading Lists brings the world of quality full-text ebooks and other digital resources from the library’s online collection easily and directly into the online learning environment for faculty and students. Contact us or see the Library OneSearch+ Reading List guide for more information.

6th Annual PCOM Research Day

Richard Saldivar Front Page, Library News

We are proud to announce the 6th Annual PCOM Research Days! All members of the PCOM community are invited to a celebration of Research, Innovation, Scholarship and Creativity with a day of poster presentations on the Georgia and Philadelphia Campuses, sponsored by the CCDA, the PCOM chapter of Sigma Xi, the National Research Honor Society and the Division of Research. Georgia Campus Georgia’s poster session will be held May 10, 2016. The official poster competition will be from 1:00 pm – 4:00 pm in the Atrium. Judging will commence at 1:00 pm. The 6th Annual PCOM Research Day Georgia keynote…

The Yellow Wall-Paper Traveling Exhibit

Richard Saldivar Front Page, Library News

The Literature of Prescription: Charlotte Perkins Gilman and “The Yellow Wall-Paper,” a National Library of Medicine traveling exhibit, reviews the role of late nineteenth-century medical and scientific experts in using the idea of female weakness to discourage women from participating in professional, creative, and intellectual life. The exhibit explores the story behind Charlotte Perkins Gilman’s indictment of the medical profession and the social conventions restricting women’s professional and creative opportunities. To preserve her health, Gilman was advised by a physician to “live as domestic a life as far as possible… And never touch pen, brush, or pencil again” as long…

Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report

PJ Grier Blood, Hot Topics in Research, Lung, March, Research Commentary

Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report BACKGROUND: We update recommendations on 12 topics that were in the 9th edition of these guidelines, and address 3 new topics. METHODS: We generate strong (Grade 1) and weak (Grade 2) recommendations based on high- (Grade A), moderate- (Grade B), and low- (Grade C) quality evidence. RESULTS: For VTE and no cancer, as long-term anticoagulant therapy, we suggest dabigatran (Grade 2B), rivaroxaban (Grade 2B), apixaban (Grade 2B), or edoxaban (Grade 2B) over vitamin K antagonist (VKA) therapy, and suggest VKA therapy over low-molecular-weight heparin (LMWH; Grade 2C). For VTE…

Atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men: systematic review and meta-analysis of cohort studies

PJ Grier Atrial Fibrillation, Cardiology, Hot Topics in Research, March

Atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men: systematic review and meta-analysis of cohort studies Abstract Objective To determine whether atrial fibrillation is a stronger risk factor for cardiovascular disease and death in women compared with men. Design Meta-analysis of cohort studies. Data sources Studies published between January 1966 and March 2015, identified through a systematic search of Medline and Embase and review of references. Eligibility for selecting studies Cohort studies with a minimum of 50 participants with and 50 without atrial fibrillation that reported sex specific associations between atrial fibrillation and all cause mortality, cardiovascular mortality,…