Month: June 2016

Case Files Collection on AccessMedicine

pjgrier Library News, New Resources

The Case Files® Collection on AccessMedicine® features a wide range of popular Case Files® series books. The collection delivers close to 1,175 real-life cases spanning the basic biomedical sciences and clinical medicine.
Designed to help students and residents learn in the context of real patients, rather than merely memorize facts. Includes real-life scenarios foster better understanding of frequently encountered cases as well as physician-patient interaction.”
Faculty can use this collection as a valuable resource for coursework, clinical rotations and to enhance preparation for shelf exams and the USMLE. Each case includes a complete discussion, clinical pearls and references, definitions of key terms, and USMLE-style review questions with detailed explanations of the correct answers.
Also, 15 additional titles are now available in the USMLE First Aid Review books collection.

DynaMed Plus is Now Available!

pjgrier Library News, New Resources
dynamed plus logo

PCOM now has access to DynaMed Plus! Get answers to your clinical questions fast!
DynaMed Plus presents critically appraised evidence from more than 500 medical journals in a quick, easy-to-read format designed for use at the point of care.
With DynaMed Plus, you will get:

  • Concise Overviews and Recommendations – accurate overviews for the most common conditions as well as evidence-based recommendations for action.
  • Micromedex® Clinical Knowledge Suite* drug content –includes medication management and lab recommendations, including IV screening, medication advisory screening and summary drug info.
  • Graphics and Images – includes over 2,500 medical graphics and images with over 1000 images from ACP.
  • Specialty Content – DynaMed Plus includes a wide array of specialty topics in areas such as infectious disease and immunology, cardiology, oncology and emergency medicine.
  • Mobile Access – DynaMed Plus is easy to access from any mobile device, from anywhere in the world. Download instructions are available here.
  • Expert Reviewers – DynaMed Plus includes subject-specific experts who review topics using the DynaMed Plus proprietary 7 Step EBM Process and the 9-Step Quality Process for creating content.

dynamed plus tablet screen
Contact us if you have any questions.

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes

pjgrier Cardiology, Hot Topics in Research

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes
The microtubule (MT) cytoskeleton can transmit mechanical signals and resist compression in contracting cardiomyocytes. How MTs perform these roles remains unclear because of difficulties in observing MTs during the rapid contractile cycle. Here, we used high spatial and temporal resolution imaging to characterize MT behavior in beating mouse myocytes. MTs deformed under contractile load into sinusoidal buckles, a behavior dependent on posttranslational “detyrosination” of α-tubulin. Detyrosinated MTs associated with desmin at force-generating sarcomeres. When detyrosination was reduced, MTs uncoupled from sarcomeres and buckled less during contraction, which allowed sarcomeres to shorten and stretch with less resistance. Conversely, increased detyrosination promoted MT buckling, stiffened the myocyte, and correlated with impaired function in cardiomyopathy. Thus, detyrosinated MTs represent tunable, compression-resistant elements that may impair cardiac function in disease.

PATRICK ROBISON, MATTHEW A. CAPORIZZO, HOSSEIN AHMADZADEH, ALEXEY I. BOGUSH, CHRISTINA YINGXIAN CHEN, KENNETH B. MARGULIES, VIVEK B. SHENOY, BENJAMIN L. PROSSER

SCIENCE 

ILLiad – InterLibrary Loan

pjgrier Library News, New Resources

Can’t find the full-text journal article in one of our many collections? The PCOM Library is proud to announce  24/7 delivery for articles with this new update for ILLiad!
ILLiad is the electronic system that allows PCOM faculty, students, and staff to request articles, books and book chapters not owned or licensed by the PCOM Library.
ILLiad improves service for students, faculty, and staff by giving them the ability to initiate and track their Interlibrary Loan requests every step of the way through a personal ILLiad account.
24/7 delivery of electronic articles direct to your desktop!
First time users will now need to create an account before accessing ILLiad. If you have already created an ILLiad account, this update will not affect you.
More information can be found on our Interlibrary Loan page as well as our ILLiad FAQ.
Contact us if you have any questions.